| Short Description : | Mouse monoclonal anti-TBL1X for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ICC/IF |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 4H2-D5-E9 |
| Isotype: | IgG2b |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | TBL1X |
| Gene ID: | 6907 |
| Uniprot ID: | TBL1X_HUMAN |
| Immunogen: | Purified recombinant human TBL1 protein fragments expressed in E.coli. |
| Tissue Specificity | Ubiquitous. |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. |
| Protein Name | F-Box-Like/Wd Repeat-Containing Protein Tbl1xSmap55Transducin Beta-Like Protein 1xTransducin-Beta-Like Protein 1 - X-Linked |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9841922 |
| Cellular Localisation | NucleusColocalized With Mecp2 To The Heterochromatin Foci |
| Alternative Antibody Names | Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1x antibodyAnti-Smap55 antibodyAnti-Transducin Beta-Like Protein 1x antibodyAnti-Transducin-Beta-Like Protein 1 - X-Linked antibodyAnti-TBL1X antibodyAnti-TBL1 antibody |
Information sourced from Uniprot.org
