| Host: | Mouse |
| Applications: | WB/ICC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-F-box-like/WD repeat-containing protein TBL1X is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 4H2-D5-E9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 ICC 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBL1X |
| Gene ID: | 6907 |
| Uniprot ID: | TBL1X_HUMAN |
| Specificity: | This antibody detects endogenous levels of TBL1X and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human TBL1 protein fragments expressed in E.coli. |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. |
| Protein Name | F-Box-Like/Wd Repeat-Containing Protein Tbl1x Smap55 Transducin Beta-Like Protein 1x Transducin-Beta-Like Protein 1 - X-Linked |
| Database Links | Reactome: R-HSA-1368082 Reactome: R-HSA-1368108 Reactome: R-HSA-1989781 Reactome: R-HSA-2122947 Reactome: R-HSA-2151201 Reactome: R-HSA-2426168 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3214815 Reactome: R-HSA-350054 Reactome: R-HSA-381340 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-9022537 Reactome: R-HSA-9022692 Reactome: R-HSA-9029569 Reactome: R-HSA-9609690 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus Colocalized With Mecp2 To The Heterochromatin Foci |
| Alternative Antibody Names | Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1x antibody Anti-Smap55 antibody Anti-Transducin Beta-Like Protein 1x antibody Anti-Transducin-Beta-Like Protein 1 - X-Linked antibody Anti-TBL1X antibody Anti-TBL1 antibody |
Information sourced from Uniprot.org