| Short Description : | Rabbit polyclonal TAX1BP3 (1-124) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAX1BP3 |
| Gene ID: | 30851 |
| Uniprot ID: | TX1B3_HUMAN |
| Immunogen Region: | 1-124 |
| Immunogen Sequence: | MSYIPGQPVTAVVQRVEIHK LRQGENLILGFSIGGGIDQD PSQNPFSEDKTDKGIYVTRV SEGGPAEIAGLQIGDKIMQV NGWDMTMVTHDQARKRLTKR SEEVVRLLVTRQSLQKAVQQ SMLS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human TAX1BP3 (NP_055419.1). |
| Tissue Specificity | Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes. |
| Function | May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. |
| Protein Name | Tax1-Binding Protein 3Glutaminase-Interacting Protein 3Tax Interaction Protein 1Tip-1Tax-Interacting Protein 1 |
| Database Links | Reactome: R-HSA-5666185 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To The Cell Membrane By Interaction With Membrane Proteins |
| Alternative Antibody Names | Anti-Tax1-Binding Protein 3 antibodyAnti-Glutaminase-Interacting Protein 3 antibodyAnti-Tax Interaction Protein 1 antibodyAnti-Tip-1 antibodyAnti-Tax-Interacting Protein 1 antibodyAnti-TAX1BP3 antibodyAnti-TIP1 antibody |
Information sourced from Uniprot.org
