| Host: |
Rabbit |
| Applications: |
WB/IF/IP |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TAB1 (205-504) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:10-1:100IP 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAB1 |
| Gene ID: |
10454 |
| Uniprot ID: |
TAB1_HUMAN |
| Immunogen Region: |
205-504 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 205-504 of human TAB1 (NP_006107.1). |
| Immunogen Sequence: |
VDHTTENEDELFRLSQLGLD AGKIKQVGIICGQESTRRIG DYKVKYGYTDIDLLSAAKSK PIIAEPEIHGAQPLDGVTGF LVLMSEGLYKALEAAHGPGQ ANQEIAAMIDTEFAKQTSLD AVAQAVVDRVKRIHSDTFAS GGERARFCPRHEDMTLLVRN FGYPLGEMSQPTPSPAPAAG GRVYPVSVPYSSAQSTSKTS VTLSLVMPSQGQMVNGAHSA STLDEATPTLTNQSPTLTL |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated at all three sites Ser-423, Thr-431 and Ser-438 by MAPK14 when cells were exposed to cellular stresses, or stimulated with TNF-alpha, IL1 or LPS. These phosphorylations inhibit TAK1 activation by a feedback control mechanism. Dephosphorylated by DUSP14 at Ser-438, leading to TAB1-MAP3K7/TAK1 complex inactivation in T-cells. Ubiquitinated by MAP3K1 with 'Lys-63'-linked polyubiquitin.leading to activation of TAK1 and of JNK and p38 MAP kinases following EGF and TGF-beta stimulation. Ubiquitinated by ITCH with 'Lys-48'-linked polyubiquitin.leading to proteasomal degradation. Ubiquitinated by RNF114 during maternal-to-zygotic transition.leading to degradation. (Microbial infection) Deubiquitinated by Y.enterocolitica YopP. O-GlcNAcylated at Ser-395 is required for full MAP3K7/TAK1 activation upon stimulation with IL-1 or osmotic stress. |
| Function | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 1Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1Tgf-Beta-Activated Kinase 1-Binding Protein 1Tak1-Binding Protein 1 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-5689880Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 1 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 1 antibodyAnti-Tak1-Binding Protein 1 antibodyAnti-TAB1 antibodyAnti-MAP3K7IP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
