| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TAAR1 (210-260 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
TAAR1 |
| Gene ID: |
134864 |
| Uniprot ID: |
TAAR1_HUMAN |
| Immunogen Region: |
210-260 aa |
| Specificity: |
Specific for TAAR1. |
| Immunogen: |
A synthetic peptide from aa region 210-260 of human TAAR1 conjugated to blue carrier Protein was used as the antigen. |
| Function | Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine. Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand. CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity. T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers. TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes. Amphetamine-binding is coupled with G(s)- or G(12)/G(13) G alpha protein subtypes. |
| Protein Name | Trace Amine-Associated Receptor 1Tar-1Trace Amine Receptor 1 |
| Database Links | Reactome: R-HSA-375280Reactome: R-HSA-418555 |
| Cellular Localisation | Endomembrane SystemEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembraneLocalizes Mainly IntracellularlyPartially Colocalizes With The Endoplasmic ReticulumAlso Found At Lower Lever At The Plasma Membrane |
| Alternative Antibody Names | Anti-Trace Amine-Associated Receptor 1 antibodyAnti-Tar-1 antibodyAnti-Trace Amine Receptor 1 antibodyAnti-TAAR1 antibodyAnti-TA1 antibodyAnti-TAR1 antibodyAnti-TRAR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
