Anti-SYT1 antibody (84-157) (STJ25763)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SYT1 (84-157) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYT1 |
| Gene ID | 6857 |
| Uniprot ID | SYT1_HUMAN |
| Immunogen Region | 84-157 |
| Immunogen Sequence | LFKKKNKKKGKEKGGKNAIN MKDVKDLGKTMKDQALKDDD AETGLTDGEEKEEPKEEEKL GKLQYSLDYDFQNN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 84-157 of human SYT1 (NP_005630.1). |
Additional Info
| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Synaptotagmin-1Synaptotagmin ISytiP65 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642Reactome: R-HSA-5250958Reactome: R-HSA-5250989Reactome: R-HSA-6794361Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-1 antibodyAnti-Synaptotagmin I antibodyAnti-Syti antibodyAnti-P65 antibodyAnti-SYT1 antibodyAnti-SVP65 antibodyAnti-SYT antibody |
Information sourced from Uniprot.org