Anti-SYNGAP1 antibody (1330-1343 aa) [R03-4F4] (STJA0010747)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human SynGAP
General Information
| Short Description | Rabbit monoclonal anti-SynGAP (1330-1343 aa) for use in WB in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-4F4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4ยฐC short term. Aliquot and store at-20ยฐC long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SYNGAP1 |
| Gene ID | 8831 |
| Uniprot ID | SYGP1_HUMAN |
| Immunogen | A synthetic peptide of human SynGAP |
| Immunogen Region | 1330-1343 aa |
Additional Info
| Post Translational Modifications | Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity. |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
| Protein Name | Ras/Rap Gtpase-Activating Protein SyngapNeuronal RasgapSynaptic Ras Gtpase-Activating Protein 1Synaptic Ras-Gap 1 |
| Database Links | Reactome: R-HSA-5658442 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ras/Rap Gtpase-Activating Protein Syngap antibodyAnti-Neuronal Rasgap antibodyAnti-Synaptic Ras Gtpase-Activating Protein 1 antibodyAnti-Synaptic Ras-Gap 1 antibodyAnti-SYNGAP1 antibodyAnti-KIAA1938 antibody |
Information sourced from Uniprot.org