| Host: | Rabbit |
| Applications: | FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Conjugation: | ABflo® 647 |
| Isotype: | IgG |
| Formulation: | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Purification: | Affinity purification |
| Dilution Range: | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Storage Instruction: | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
| Gene Symbol: | SDC4 |
| Gene ID: | 6385 |
| Uniprot ID: | SDC4_HUMAN |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Tissue Specificity | Detected in fibroblasts (at protein level). Also expressed in epithelial cells. |
| Post Translational Modifications | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. O-glycosylated.contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate. |
| Function | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. |
| Protein Name | Syndecan-4Synd4AmphiglycanRyudocan Core Protein |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-2022928Reactome: R-HSA-2024096Reactome: R-HSA-202733Reactome: R-HSA-3000170Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3656237Reactome: R-HSA-3656253Reactome: R-HSA-4420332Reactome: R-HSA-9694614Reactome: R-HSA-975634Reactome: R-HSA-9820960Reactome: R-HSA-9833110 |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinSecretedShedding Of The Ectodomain Produces A Soluble FormIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Syndecan-4 antibodyAnti-Synd4 antibodyAnti-Amphiglycan antibodyAnti-Ryudocan Core Protein antibodyAnti-SDC4 antibody |
Information sourced from Uniprot.org