| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat/Dog/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Synaptotagmin-10 (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments in Human Kidney, Lung and Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SYT10 |
| Gene ID: | 341359 |
| Uniprot ID: | SYT10_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_945343.1 |
| Immunogen Sequence: | CRTGLDAEGLGRDH |
| Function | Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes.both actions contribute to triggering exocytosis. |
| Protein Name | Synaptotagmin-10Synaptotagmin XSytx |
| Database Links | Reactome: R-HSA-6794361Reactome: R-HSA-9768919 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinLocalizes To Neuronal Vesicles Containing Igf1 That Are Not Enriched At SynapsesDoes Not Colocalize With Synaptic Vesicles Or With The Golgi Apparatus |
| Alternative Antibody Names | Anti-Synaptotagmin-10 antibodyAnti-Synaptotagmin X antibodyAnti-Sytx antibodyAnti-SYT10 antibody |
Information sourced from Uniprot.org