Human neuroendocrine tumor stained with anti-Synaptophysin antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells.

Anti-Synaptophysin antibody (200-300aa) [ZM208] (STJ180393)

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STJ180393
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Synaptophysin (200-300aa) is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : ZM208
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: SYP
Gene ID: 6855
Uniprot ID: SYPH_HUMAN
Immunogen Region: 200-300aa
Specificity: Positive control: Pancreas
Immunogen: Synthetic peptide within Human Synaptophysin aa 200-300
Tissue Specificity Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3. Expressed in the putamen (at protein level).
Post Translational Modifications Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. Phosphorylated by SRC.
Function Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
Protein Name Synaptophysin
Major Synaptic Vesicle Protein P38
Database Links Reactome: R-HSA-9662360
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Multi-Pass Membrane Protein
Synapse
Synaptosome
Alternative Antibody Names Anti-Synaptophysin antibody
Anti-Major Synaptic Vesicle Protein P38 antibody
Anti-SYP antibody

Information sourced from Uniprot.org

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