Host: |
Rabbit |
Applications: |
IF/ICC/ELISA |
Reactivity: |
Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Monoclonal |
Clone ID: |
SRM |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Gene Symbol: |
SYN1 |
Gene ID: |
6853 |
Uniprot ID: |
SYN1_HUMAN |
Immunogen Region: |
401-500 aa |
Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 401-500 of human Synapsin-1 (NP_008881.2, ). |
Immunogen Sequence: |
EDKQLIVELVVNKMAQALPR QRQRDASPGRGSHGQTPSPG ALPLGRQTSQQPAGPPAQQR PPPQGGPPQPGPGPQRQGPP LQQRPPPQGQQHLSGLGPPA |
Post Translational Modifications | Substrate of different protein kinases. Phosphorylated by CaMK2 and MAPK1. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover and neurotransmitter release . |
Function | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. |
Protein Name | Synapsin-1Brain Protein 4.1Synapsin I |
Database Links | Reactome: R-HSA-181429Reactome: R-HSA-212676Reactome: R-HSA-9662360 |
Cellular Localisation | SynapseGolgi ApparatusPresynapseCytoplasmic VesicleSecretory VesicleSynaptic VesicleDissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential FiringIn A Step That Precedes Fusion Of Vesicles With The Plasma MembraneReclusters To Presynapses After The Cessation Of Synaptic Activity |
Alternative Antibody Names | Anti-Synapsin-1 antibodyAnti-Brain Protein 4.1 antibodyAnti-Synapsin I antibodyAnti-SYN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance