Anti-Synapsin-1 antibody (401-500 aa) [SRM] (STJ11107349)

SKU:
STJ11107349

Current Stock:
Host: Rabbit
Applications: IF/ICC/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Monoclonal
Clone ID: SRM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IF/ICC:1:200-1:800
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: SYN1
Gene ID: 6853
Uniprot ID: SYN1_HUMAN
Immunogen Region: 401-500 aa
Specificity: A synthetic peptide corresponding to a sequence within amino acids 401-500 of human Synapsin-1 (NP_008881.2, ).
Immunogen Sequence: EDKQLIVELVVNKMAQALPR QRQRDASPGRGSHGQTPSPG ALPLGRQTSQQPAGPPAQQR PPPQGGPPQPGPGPQRQGPP LQQRPPPQGQQHLSGLGPPA
Post Translational Modifications Substrate of different protein kinases. Phosphorylated by CaMK2 and MAPK1. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover and neurotransmitter release .
Function Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Protein Name Synapsin-1
Brain Protein 4.1
Synapsin I
Database Links Reactome: R-HSA-181429
Reactome: R-HSA-212676
Reactome: R-HSA-9662360
Cellular Localisation Synapse
Golgi Apparatus
Presynapse
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle
Dissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential Firing
In A Step That Precedes Fusion Of Vesicles With The Plasma Membrane
Reclusters To Presynapses After The Cessation Of Synaptic Activity
Alternative Antibody Names Anti-Synapsin-1 antibody
Anti-Brain Protein 4.1 antibody
Anti-Synapsin I antibody
Anti-SYN1 antibody

Information sourced from Uniprot.org

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