| Function | Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. |
| Protein Name | Synaptonemal Complex Protein 1Scp-1Cancer/Testis Antigen 8Ct8 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereIn Tripartite Segments Of Synaptonemal ComplexesBetween Lateral Elements In The NucleusIts N-Terminus Is Found Towards The Center Of The Synaptonemal Complex While The C-Terminus Extends Well Into The Lateral Domain Of The Synaptonemal ComplexOnly Rarely Detected At Centromeres During Leptotene And ZygoteneDetected At Centromeres During Mid-DiploteneWhen It Is No Longer Present Along Chromosome ArmsNo Longer Detected At Centromeres At Later Stages Of Meiosis |
| Alternative Antibody Names | Anti-Synaptonemal Complex Protein 1 antibodyAnti-Scp-1 antibodyAnti-Cancer/Testis Antigen 8 antibodyAnti-Ct8 antibodyAnti-SYCP1 antibodyAnti-SCP1 antibody |
Information sourced from Uniprot.org
