| Post Translational Modifications | Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA).the toxin probably binds via extracellular loop 4. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD).BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E. (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E).the toxin probably binds via extracellular loop 4. It probably requires glycosylation of Asn-573. |
| Protein Name | Synaptic Vesicle Glycoprotein 2aSynaptic Vesicle Protein 2Synaptic Vesicle Protein 2aCalcium Regulator Sv2a |
| Database Links | |
| Cellular Localisation | PresynapseCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Chromaffin GranulesNot Present In Adrenal MicrosomesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The PancreasColocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Nanobody Names | Anti-Synaptic Vesicle Glycoprotein 2a nanobodyAnti-Synaptic Vesicle Protein 2 nanobodyAnti-Synaptic Vesicle Protein 2a nanobodyAnti-Calcium Regulator Sv2a nanobodyAnti-Sv2a nanobodyAnti-Kiaa0736 nanobodyAnti-Sv2 nanobody |
Information sourced from Uniprot.org
