Anti-SV2A antibody (N-Term) (STJ13102134)

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STJ13102134-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SV2A (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SV2A
Gene ID: 9900
Uniprot ID: SV2A_HUMAN
Immunogen Region: N-Term
Specificity: Specific for SV2A.
Immunogen: A synthetic peptide from n-terminal region of human Synaptic vesicle glycoprotein 2A (SV2A) conjugated to blue carrier protein was used as the antigen.
Function Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
Protein Name Synaptic Vesicle Glycoprotein 2a
Database Links Reactome: R-HSA-5250955
Reactome: R-HSA-5250968
Reactome: R-HSA-5250981
Reactome: R-HSA-5250992
Cellular Localisation Presynapse
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Multi-Pass Membrane Protein
Enriched In Chromaffin Granules
Not Present In Adrenal Microsomes
Associated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas
Colocalizes With Atp2b1 At Photoreceptor Synaptic Terminals
Alternative Antibody Names Anti-Synaptic Vesicle Glycoprotein 2a antibody
Anti-SV2A antibody
Anti-KIAA0736 antibody
Anti-PSEC0174 antibody

Information sourced from Uniprot.org

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