| Host: | Goat |
| Applications: | Pep-ELISA/IF |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SV2A (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary testing showed a band at approx 80kDa in Mouse and Rat Brain lysate after 1.5µg/ml antibody staining (calculated MW of 82.6kDa according to Mouse NP_071313.1 and Rat NP_4765 |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SV2A |
| Gene ID: | 9900 |
| Uniprot ID: | SV2A_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_055664.3; NP_001265648.1 |
| Immunogen Sequence: | TVELYPSDKRTTA |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2a |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981Reactome: R-HSA-5250992 |
| Cellular Localisation | PresynapseCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Chromaffin GranulesNot Present In Adrenal MicrosomesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The PancreasColocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2a antibodyAnti-SV2A antibodyAnti-KIAA0736 antibodyAnti-PSEC0174 antibody |
Information sourced from Uniprot.org