Anti-SV2A antibody (356-447) (STJ119880)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SV2A (356-447) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SV2A |
| Gene ID | 9900 |
| Uniprot ID | SV2A_HUMAN |
| Immunogen Region | 356-447 |
| Immunogen Sequence | ESPRFFLENGKHDEAWMVLK QVHDTNMRAKGHPERVFSVT HIKTIHQEDELIEIQSDTGT WYQRWGVRALSLGGQVWGNF LSCFGPEYRRIT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 356-447 of human SV2A (NP_055664.3). |
Additional Info
| Post Translational Modifications | Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2a |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981Reactome: R-HSA-5250992 |
| Cellular Localisation | PresynapseCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Chromaffin GranulesNot Present In Adrenal MicrosomesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The PancreasColocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2a antibodyAnti-SV2A antibodyAnti-KIAA0736 antibodyAnti-PSEC0174 antibody |
Information sourced from Uniprot.org