| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SV2A |
| Gene ID: | 9900 |
| Uniprot ID: | SV2A_HUMAN |
| Immunogen Region: | 356-447 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-447 of human SV2A (NP_055664.3). |
| Immunogen Sequence: | ESPRFFLENGKHDEAWMVLK QVHDTNMRAKGHPERVFSVT HIKTIHQEDELIEIQSDTGT WYQRWGVRALSLGGQVWGNF LSCFGPEYRRIT |
| Post Translational Modifications | Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2a |
| Database Links | Reactome: R-HSA-5250955 Reactome: R-HSA-5250968 Reactome: R-HSA-5250981 Reactome: R-HSA-5250992 |
| Cellular Localisation | Presynapse Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Multi-Pass Membrane Protein Enriched In Chromaffin Granules Not Present In Adrenal Microsomes Associated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas Colocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2a antibody Anti-SV2A antibody Anti-KIAA0736 antibody Anti-PSEC0174 antibody |
Information sourced from Uniprot.org