| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Synaptic vesicle glycoprotein 2A (30-80 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SV2A |
| Gene ID: | 9900 |
| Uniprot ID: | SV2A_HUMAN |
| Immunogen Region: | 30-80 aa |
| Specificity: | SV2A Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid range 30-80 |
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2a |
| Database Links | Reactome: R-HSA-5250955 Reactome: R-HSA-5250968 Reactome: R-HSA-5250981 Reactome: R-HSA-5250992 |
| Cellular Localisation | Presynapse Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Multi-Pass Membrane Protein Enriched In Chromaffin Granules Not Present In Adrenal Microsomes Associated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas Colocalizes With Atp2b1 At Photoreceptor Synaptic Terminals |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2a antibody Anti-SV2A antibody Anti-KIAA0736 antibody Anti-PSEC0174 antibody |
Information sourced from Uniprot.org
