Anti-SURF4 antibody (144-157 aa) [R07-1F1] (STJA0012159)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human SURF4
General Information
| Short Description | Rabbit monoclonal anti-Surfeit Locus Protein 4 (144-157 aa) for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-1F1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SURF4 |
| Gene ID | 6836 |
| Uniprot ID | SURF4_HUMAN |
| Immunogen | A synthetic peptide of human SURF4 |
| Immunogen Region | 144-157 aa |
Additional Info
| Function | Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. |
| Protein Name | Surfeit Locus Protein 4 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811434 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneGolgi Apparatus MembraneActive At Endoplasmic Reticulum Exit Sites (Eres) Where It Is Incorporated Together With Its Lipoprotein Cargos Into Copii-Coated VesiclesFrom The Golgi It Is Recycled Back To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Surfeit Locus Protein 4 antibodyAnti-SURF4 antibodyAnti-SURF-4 antibody |
Information sourced from Uniprot.org