| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUPT20H |
| Gene ID: | 55578 |
| Uniprot ID: | SP20H_HUMAN |
| Immunogen Region: | 580-779 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-779 of human SUPT20H (NP_001014308.2). |
| Immunogen Sequence: | NLSGLLPSGGLLPNALPSAM QAASQAGVPFGLKNTSSLRP LNLLQLPGGSLIFNTLQQQQ QQLSQFTPQQPQQPTTCSPQ QPGEQGSEQGSTSQEQALSA QQAAVINLTGVGSFMQSQAA VLSQLGSAENRPEQSLPQQR FQLSSAFQQQQQQIQQLRFL QHQMAMAAAAAQTAQLHHHR HTGSQSKSKMKRGTPTTPKF |
| Tissue Specificity | Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues. |
| Function | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy. |
| Protein Name | Transcription Factor Spt20 HomologP38-Interacting ProteinP38ip |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Spt20 Homolog antibodyAnti-P38-Interacting Protein antibodyAnti-P38ip antibodyAnti-SUPT20H antibodyAnti-C13orf19 antibodyAnti-FAM48A antibodyAnti-FP757 antibody |
Information sourced from Uniprot.org