| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-SUN2 (618-717) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S1MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SUN2 |
| Gene ID: |
25777 |
| Uniprot ID: |
SUN2_HUMAN |
| Immunogen Region: |
618-717 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 618-717 of human SUN2 (Q9UH99). |
| Immunogen Sequence: |
RIRPTAVTLEHVPKALSPNS TISSAPKDFAIFGFDEDLQQ EGTLLGKFTYDQDGEPIQTF HFQAPTMATYQVVELRILTN WGHPEYTCIYRFRVHGEPAH |
| Tissue Specificity | Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. |
| Post Translational Modifications | The disulfide bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfide bond is proposed to be conserved in LINC complexes involved in force transmission. |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins.SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis.SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. |
| Protein Name | Sun Domain-Containing Protein 2Protein Unc-84 Homolog BRab5-Interacting ProteinRab5ipSad1/Unc-84 Protein-Like 2 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Type Ii Membrane ProteinNucleus EnvelopeEndosome Membrane |
| Alternative Antibody Names | Anti-Sun Domain-Containing Protein 2 antibodyAnti-Protein Unc-84 Homolog B antibodyAnti-Rab5-Interacting Protein antibodyAnti-Rab5ip antibodyAnti-Sad1/Unc-84 Protein-Like 2 antibodyAnti-SUN2 antibodyAnti-FRIGG antibodyAnti-KIAA0668 antibodyAnti-RAB5IP antibodyAnti-UNC84B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
