| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUMO2 |
| Gene ID: | 6613 |
| Uniprot ID: | SUMO2_HUMAN |
| Immunogen Region: | 1-95 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human SUMO2/3 (NP_008868.3). |
| Immunogen Sequence: | MADEKPKEGVKTENNDHINL KVAGQDGSVVQFKIKRHTPL SKLMKAYCERQGLSMRQIRF RFDGQPINETDTPAQLEMED EDTIDVFQQQTGGVY |
| Tissue Specificity | Broadly expressed. |
| Post Translational Modifications | Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer. |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX. |
| Protein Name | Small Ubiquitin-Related Modifier 2Sumo-2Hsmt3Smt3 Homolog 2Sumo-3Sentrin-2Ubiquitin-Like Protein Smt3bSmt3b |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-3065676Reactome: R-HSA-3065678Reactome: R-HSA-3065679Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-3899300Reactome: R-HSA-4085377Reactome: R-HSA-4090294Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5693607Reactome: R-HSA-5696395Reactome: R-HSA-9843940 |
| Cellular Localisation | NucleusPml Body |
| Alternative Antibody Names | Anti-Small Ubiquitin-Related Modifier 2 antibodyAnti-Sumo-2 antibodyAnti-Hsmt3 antibodyAnti-Smt3 Homolog 2 antibodyAnti-Sumo-3 antibodyAnti-Sentrin-2 antibodyAnti-Ubiquitin-Like Protein Smt3b antibodyAnti-Smt3b antibodyAnti-SUMO2 antibodyAnti-SMT3B antibodyAnti-SMT3H2 antibody |
Information sourced from Uniprot.org