| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sulfotransferase 1E1 (209-259) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SULT1E1 |
| Gene ID: |
6783 |
| Uniprot ID: |
ST1E1_HUMAN |
| Immunogen Region: |
209-259 |
| Specificity: |
This antibody detects endogenous levels of human ST1E1 |
| Immunogen: |
Synthesized peptide derived from human ST1E1 AA range: 209-259 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1e1St1e1Est-1Estrogen SulfotransferaseSulfotransferase - Estrogen-Preferring |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Sulfotransferase 1e1 antibodyAnti-St1e1 antibodyAnti-Est-1 antibodyAnti-Estrogen Sulfotransferase antibodyAnti-Sulfotransferase - Estrogen-Preferring antibodyAnti-SULT1E1 antibodyAnti-STE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
