| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds. Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol. Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration. Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. |
| Protein Name | Sulfotransferase 1c2St1c2Sulfotransferase 1c1Sult1c#1Humsultc2 |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | CytoplasmLysosomeMitochondrion |
| Alternative Antibody Names | Anti-Sulfotransferase 1c2 antibodyAnti-St1c2 antibodyAnti-Sulfotransferase 1c1 antibodyAnti-Sult1c#1 antibodyAnti-Humsultc2 antibodyAnti-SULT1C2 antibodyAnti-SULT1C1 antibody |
Information sourced from Uniprot.org
