| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SULF1 |
| Gene ID: | 23213 |
| Uniprot ID: | SULF1_HUMAN |
| Immunogen Region: | 480-610 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-610 of human SULF1 (NP_001121676.1). |
| Immunogen Sequence: | SDLLTVRQSTRNLYARGFHD KDKECSCRESGYRASRSQRK SQRQFLRNQGTPKYKPRFVH TRQTRSLSVEFEGEIYDINL EEEEELQVLQPRNIAKRHDE GHKGPRDLQASSGGNRGRML ADSSNAVGPPT |
| Tissue Specificity | Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines. |
| Post Translational Modifications | Processing by furin produces a secreted form. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. |
| Protein Name | Extracellular Sulfatase Sulf-1 Hsulf-1 Arylsulfatase N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form |
| Cellular Localisation | Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cell Surface Extracellular Sulfatase Sulf-2 Secreted Form: Secreted |
| Alternative Antibody Names | Anti-Extracellular Sulfatase Sulf-1 antibody Anti-Hsulf-1 antibody Anti-Arylsulfatase antibody Anti-N-Acetylglucosamine-6-Sulfatase Cleaved Into - Extracellular Sulfatase Sulf-2 Secreted Form antibody Anti-SULF1 antibody Anti-KIAA1077 antibody |
Information sourced from Uniprot.org