Anti-SUGCT antibody (1-250) (STJ117804)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SUGCT (1-250) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SUGCT |
| Gene ID | 79783 |
| Uniprot ID | SUCHY_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MPSETHAMLATLARVAALRR TCLFSGRGGGRGLWTGRPQS DMNNIKPLEGVKILDLTRVL AGPFATMNLGDLGAEVIKVE RPGAGDDTRTWGPPFVGTES TYYLSVNRNKKSIAVNIKDP KGVKIIKELAAVCDVFVENY VPGKLSAMGLGYEDIDEIAP HIIYCSITGYGQTGPISQRA GYDAVASAVSGLMHITGPEN GDPVRPGVAMTDLATGLYAY GAIMAGLIQKYKTGKGLFI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SUGCT (NP_001180240.1). |
Additional Info
| Tissue Specificity | Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined. |
| Function | Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis. |
| Protein Name | Succinyl-Coa -Glutarate Coa-TransferaseDermal Papilla-Derived Protein 13Dicarboxyl-Coa -Dicarboxylic Acid Coenzyme A Transferase SugctSuccinate--Hydroxymethylglutarate Coa-Transferase |
| Database Links | |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Succinyl-Coa -Glutarate Coa-Transferase antibodyAnti-Dermal Papilla-Derived Protein 13 antibodyAnti-Dicarboxyl-Coa -Dicarboxylic Acid Coenzyme A Transferase Sugct antibodyAnti-Succinate--Hydroxymethylglutarate Coa-Transferase antibodyAnti-SUGCT antibodyAnti-C7orf10 antibodyAnti-DERP13 antibody |
Information sourced from Uniprot.org