Anti-Substance P antibody [R58-3Q-3] (STJA0035456)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Substance P
General Information
| Short Description | Rabbit monoclonal anti-Substance P for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R58-3Q-3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TAC1 |
| Gene ID | 6863 |
| Uniprot ID | TKN1_HUMAN |
| Immunogen | A synthesized peptide derived from human Substance P |
Additional Info
| Post Translational Modifications | Substance P: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. |
| Protein Name | Protachykinin-1Ppt Cleaved Into - Substance P - Neurokinin ANkaNeuromedin LSubstance K - Neuropeptide KNpk - Neuropeptide Gamma - C-Terminal-Flanking Peptide |
| Database Links | Reactome: R-HSA-380095Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protachykinin-1 antibodyAnti-Ppt Cleaved Into - Substance P - Neurokinin A antibodyAnti-Nka antibodyAnti-Neuromedin L antibodyAnti-Substance K - Neuropeptide K antibodyAnti-Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide antibodyAnti-TAC1 antibodyAnti-NKA antibodyAnti-NKNA antibodyAnti-TAC2 antibody |
Information sourced from Uniprot.org