Anti-STXBP5L antibody (990-1040 aa) (STJ194491)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human STB5L at the amino acid range 990-1040
General Information
| Short Description | Rabbit polyclonal anti-Syntaxin-binding protein 5-like giant larvae protein homolog 4 (990-1040 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STXBP5L |
| Gene ID | 9515 |
| Uniprot ID | STB5L_HUMAN |
| Immunogen | Synthesized peptide derived from the human STB5L at the amino acid range 990-1040 |
| Immunogen Region | 990-1040 aa |
| Specificity | This antibody detects endogenous levels of STB5L at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion. Phosphorylated on serine residues in response to glucose or phorbol esters. Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. |
| Function | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth. |
| Protein Name | Syntaxin-Binding Protein 5-LikeLethal(2 Giant Larvae Protein Homolog 4Tomosyn-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinMembraneCytoplasmicAnd Associated With Vesicular Membranes And The Plasma Membrane |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 5-Like antibodyAnti-Lethal(2 Giant Larvae Protein Homolog 4 antibodyAnti-Tomosyn-2 antibodyAnti-STXBP5L antibodyAnti-KIAA1006 antibodyAnti-LLGL4 antibody |
Information sourced from Uniprot.org