| Short Description : | Goat polyclonal antibody anti-STS2/TULA (470-482) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/WB/IHC |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 70kDa band observed in Human Spleen lysates (calculated MW of 69.8kDa according to NP_001001895.1). Recommended concentration: 1-3µg/ml.IHC: In paraffin embedded Human Breas |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | UBASH3A |
| Gene ID: | 53347 |
| Uniprot ID: | UBS3A_HUMAN |
| Accession Number: | NP_061834.1; NP_001001895.1 |
| Immunogen Region: | 470-482 |
| Immunogen Sequence: | DSGIRISSVFASP |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_061834.1; NP_001001895.1). |
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. |
| Protein Name | Ubiquitin-Associated And Sh3 Domain-Containing Protein ACbl-Interacting Protein 4Clip4Suppressor Of T-Cell Receptor Signaling 2Sts-2T-Cell Ubiquitin Ligand 1Tula-1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin-Associated And Sh3 Domain-Containing Protein A antibodyAnti-Cbl-Interacting Protein 4 antibodyAnti-Clip4 antibodyAnti-Suppressor Of T-Cell Receptor Signaling 2 antibodyAnti-Sts-2 antibodyAnti-T-Cell Ubiquitin Ligand 1 antibodyAnti-Tula-1 antibodyAnti-UBASH3A antibodyAnti-STS2 antibody |
Information sourced from Uniprot.org
![Immunoprecipitation analysis of 200 Mu g extracts of HT-29 cells, using 3 Mu g [KD Validated] HDAC1 Rabbit polyclonal antibody (STJ23928). Western blot was performed from the immunoprecipitate using HDAC1 antibody (STJ23928) at a dilution of 1:1000.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/99763/385130/STJ23928_1__20693.1713153988.jpg?c=1 "Immunoprecipitation analysis of 200 Mu g extracts of HT-29 cells, using 3 Mu g [KD Validated] HDAC1 Rabbit polyclonal antibody (STJ23928). Western blot was performed from the immunoprecipitate using HDAC1 antibody (STJ23928) at a dilution of 1:1000.")
