Anti-STS2/TULA antibody (470-482) (STJ72562)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-STS2/TULA (470-482) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 70kDa band observed in Human Spleen lysates (calculated MW of 69.8kDa according to NP_001001895.1). Recommended concentration: 1-3ยตg/ml.IHC: In paraffin embedded Human Breas |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | UBASH3A |
| Gene ID | 53347 |
| Uniprot ID | UBS3A_HUMAN |
| Accession Number | NP_061834.1; NP_001001895.1 |
| Immunogen Region | 470-482 |
| Immunogen Sequence | DSGIRISSVFASP |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_061834.1; NP_001001895.1). |
Additional Info
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. |
| Protein Name | Ubiquitin-Associated And Sh3 Domain-Containing Protein ACbl-Interacting Protein 4Clip4Suppressor Of T-Cell Receptor Signaling 2Sts-2T-Cell Ubiquitin Ligand 1Tula-1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin-Associated And Sh3 Domain-Containing Protein A antibodyAnti-Cbl-Interacting Protein 4 antibodyAnti-Clip4 antibodyAnti-Suppressor Of T-Cell Receptor Signaling 2 antibodyAnti-Sts-2 antibodyAnti-T-Cell Ubiquitin Ligand 1 antibodyAnti-Tula-1 antibodyAnti-UBASH3A antibodyAnti-STS2 antibody |
Information sourced from Uniprot.org