Anti-STK38 antibody (390-470 aa) (STJ190112)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 390-470
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase 38 (390-470 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STK38 |
| Gene ID | 11329 |
| Uniprot ID | STK38_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 390-470 |
| Immunogen Region | 390-470 aa |
| Specificity | STK38 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. |
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation. |
| Protein Name | Serine/Threonine-Protein Kinase 38Ndr1 Protein KinaseNuclear Dbf2-Related Kinase 1 |
| Database Links | Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmChromosomeLocalizes To Dna Double-Strand Breaks In Response To Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 38 antibodyAnti-Ndr1 Protein Kinase antibodyAnti-Nuclear Dbf2-Related Kinase 1 antibodyAnti-STK38 antibodyAnti-NDR1 antibody |
Information sourced from Uniprot.org