| Function | DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions. Required for monoubiquitination of UVSSA. Regulates repositioning and stabilization of UVSSA within the TC-NER complex. Stimulates ubiquitination of RNAPII complex member RBP1. Also binds to RNA and regulates the expression levels of many mRNAs. |
| Protein Name | Winged Helix Repair Factor 1Inactive Serine/Threonine-Protein Kinase 19Protein G11Protein Rp1Tandem Winged Helix Protein Formerly Known As Stk19 |
| Database Links | |
| Cellular Localisation | Isoform 4: NucleusIsoform 3: NucleusVery Tightly Chromatin-AssociatedIsoform 1: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Winged Helix Repair Factor 1 antibodyAnti-Inactive Serine/Threonine-Protein Kinase 19 antibodyAnti-Protein G11 antibodyAnti-Protein Rp1 antibodyAnti-Tandem Winged Helix Protein Formerly Known As Stk19 antibodyAnti-WHR1 antibodyAnti-G11 antibodyAnti-RP1 antibodyAnti-STK19 antibodyAnti-TWH19 antibody |
Information sourced from Uniprot.org
