Anti-STIM2 antibody (600-650) {Biotin} (STJ503144)

SKU:
STJ503144-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-STIM2 (600-650) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.51-0.58 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: STIM2
Gene ID: 57620
Uniprot ID: STIM2_HUMAN
Immunogen Region: 600-650
Immunogen: Synthetic peptide taken within amino acid region 600-650 on human STIM2 protein.
Tissue Specificity Expressed in all tissues and tumor cell lines examined.
Post Translational Modifications Glycosylated. Phosphorylated predominantly on Ser residues.
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
Protein Name Stromal Interaction Molecule 2
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Dynamically Translocates From A Uniform Endoplasmic Reticulum Distribution To Punctual Endoplasmic Reticulum-Plasma Membrane Junctions In Response To Decrease In Endoplasmic Reticulum Ca(2+) Concentration
Alternative Antibody Names Anti-Stromal Interaction Molecule 2 antibody
Anti-STIM2 antibody
Anti-KIAA1482 antibody

Information sourced from Uniprot.org

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