Anti-STAP2/BKS antibody (391-403) (STJ70034)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-STAP2/BKS (391-403) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 49kDa band observed in Human Breast lysates (calculated MW of 49.6kDa according to NP_060190.2). Recommended concentration: 0.3-1ยตg/ml.IHC: Paraffin embedded Human Small I |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | STAP2 |
| Gene ID | 55620 |
| Uniprot ID | STAP2_HUMAN |
| Accession Number | NP_060190.2; NP_001013863.1 |
| Immunogen Region | 391-403 |
| Immunogen Sequence | LQKKLEKRRALEH |
| Specificity | This antibody is expected to recognize isoform 1 (NP_060190.2) and isoform 2 (NP_001013863.1). |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. |
| Function | Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. |
| Protein Name | Signal-Transducing Adaptor Protein 2Stap-2Breast Tumor Kinase SubstrateBrk Substrate |
| Database Links | Reactome: R-HSA-8849474Reactome: R-HSA-9707564 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Signal-Transducing Adaptor Protein 2 antibodyAnti-Stap-2 antibodyAnti-Breast Tumor Kinase Substrate antibodyAnti-Brk Substrate antibodyAnti-STAP2 antibodyAnti-BKS antibody |
Information sourced from Uniprot.org