Anti-STAM antibody (120-210) (STJ25712)

Name: Anti-STAM antibody (120-210) (STJ25712)
SKU: STJ25712
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25712

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Short Description	Rabbit polyclonal STAM (120-210) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:200-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	STAM
Gene ID	8027
Uniprot ID	STAM1_HUMAN
Immunogen Region	120-210
Immunogen Sequence	KNDPQLSLISAMIKNLKEQG VTFPAIGSQAAEQAKASPAL VAKDPGTVANKKEEEDLAKA IELSLKEQRQQSTTLSTLYP STSSLLTNHQH
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human STAM (NP_003464.1).

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. Ubiquitinated by ITCH.
Function	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. (Microbial infection) Plays an important role in Dengue virus entry.
Protein Name	Signal Transducing Adapter Molecule 1 Stam-1
Database Links	Reactome: R-HSA-182971 Reactome: R-HSA-5689901 Reactome: R-HSA-6807004 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8875360 Reactome: R-HSA-9013420 Reactome: R-HSA-917729
Cellular Localisation	Cytoplasm Early Endosome Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Antibody Names	Anti-Signal Transducing Adapter Molecule 1 antibody Anti-Stam-1 antibody Anti-STAM antibody Anti-STAM1 antibody

Information sourced from Uniprot.org