| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STAG1 (930-1140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STAG1 |
| Gene ID: |
10274 |
| Uniprot ID: |
STAG1_HUMAN |
| Immunogen Region: |
930-1140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 930-1140 of human STAG1 (NP_005853.2). |
| Immunogen Sequence: |
LFNELVQEQGPNLDRTSAHV SGIKELARRFALTFGLDQIK TREAVATLHKDGIEFAFKYQ NQKGQEYPPPNLAFLEVLSE FSSKLLRQDKKTVHSYLEKF LTEQMMERREDVWLPLISYR NSLVTGGEDDRMSVNSGSSS SKTSSVRNKKGRPPLHKKRV EDESLDNTWLNRTDTMIQTP GPLPAPQLTSTVLRENSRPM GDQIQEPESEH |
| Post Translational Modifications | Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation. |
| Function | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Protein Name | Cohesin Subunit Sa-1Scc3 Homolog 1Stromal Antigen 1 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinBefore Prophase It Is Scattered Along Chromosome ArmsDuring ProphaseMost Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk1Except At CentromeresWhere Cohesin Complexes RemainAt AnaphaseThe Rad21 Subunit Of Cohesin Is CleavedLeading To The Dissociation Of The Complex From ChromosomesAllowing Chromosome Separation |
| Alternative Antibody Names | Anti-Cohesin Subunit Sa-1 antibodyAnti-Scc3 Homolog 1 antibodyAnti-Stromal Antigen 1 antibodyAnti-STAG1 antibodyAnti-SA1 antibodyAnti-SCC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
