| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DGKD (960-1140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DGKD |
| Gene ID: |
8527 |
| Uniprot ID: |
DGKD_HUMAN |
| Immunogen Region: |
960-1140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 960-1140 of human DGKD (NP_690618.2). |
| Immunogen Sequence: |
LPRPPSCSLHPEMLSEEEAT QMDQFGQAAGVLIHSIREIA QSHRDMEQELAHAVNASSKS MDRVYGKPRTTEGLNCSFVL EMVNNFRALRSETELLLSGK MALQLDPPQKEQLGSALAEM DRQLRRLADTPWLCQSAEPG DEESVMLDLAKRSRSGKFRL VTKFKKEKNNKNKEAHSSLG A |
| Tissue Specificity | Isoform 2: Widely expressed. Isoform 1: Only detected in ovary, and to a lesser extent in spleen. |
| Post Translational Modifications | Isoform 1: Phosphorylated. Phosphorylation by PKC induced by phorbol esters prevents homooligomerization and promotes association with membranes. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis. |
| Protein Name | Diacylglycerol Kinase DeltaDag Kinase Delta130 Kda Diacylglycerol KinaseDiglyceride Kinase DeltaDgk-Delta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | MembraneClathrin-Coated PitCytoplasmIsoform 1: Cell MembranePeripheral Membrane ProteinIsoform 1 Translocation From Cytoplasm To The Plasma Membrane Is Induced By Phorbol EstersPhorbol Esters Induce The Conversion Into The Monomeric Form Which Can Translocate To The Plasma Membrane |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Delta antibodyAnti-Dag Kinase Delta antibodyAnti-130 Kda Diacylglycerol Kinase antibodyAnti-Diglyceride Kinase Delta antibodyAnti-Dgk-Delta antibodyAnti-DGKD antibodyAnti-KIAA0145 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
