| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CEP135 (841-1140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CEP135 |
| Gene ID: |
9662 |
| Uniprot ID: |
CP135_HUMAN |
| Immunogen Region: |
841-1140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 841-1140 of human CEP135 (NP_079285.2). |
| Immunogen Sequence: |
LEAAVQEKEEMKSRVHKYIT EVSRWESLMAAKEKENQDLL DRFQMLHNRAEDWEVKAHQA EGESSSVRLELLSIDTERRH LRERVELLEKEIQEHINAHH AYESQISSMAKAMSRLEEEL RHQEDEKATVLNDLSSLREL CIKLDSGKDIMTQQLNSKNL EFERVVVELENVKSESDLLK KQLSNERHTVKNLESLLATN RDKEFHSHLTSHEKDTEIQL LKEKLTLSESKLTSQSREN |
| Function | Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. |
| Protein Name | Centrosomal Protein Of 135 KdaCep135Centrosomal Protein 4 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleDuring Centriole BiogenesisIt Is Concentrated Within The Proximal Lumen Of Both Parental Centrioles And Procentrioles |
| Alternative Antibody Names | Anti-Centrosomal Protein Of 135 Kda antibodyAnti-Cep135 antibodyAnti-Centrosomal Protein 4 antibodyAnti-CEP135 antibodyAnti-CEP4 antibodyAnti-KIAA0635 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
