| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 4 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ST3GAL4 |
| Gene ID: | 6484 |
| Uniprot ID: | SIA4C_HUMAN |
| Specificity: | This antibody detects endogenous levels of ST3GAL4 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human ST3GAL4 |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4 Alpha 2 -3-St 4 Beta-Galactoside Alpha-2 -3-Sialyltransferase 4 Alpha 2 -3-Sialyltransferase Iv Gal-Nac6s Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase Gal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase N-Acetyllactosaminide Alpha-2 -3-Sialyltransferase Sat-3 St-4 St3gal Iv St3galiv St3gala.2 Stz Sialyltransferase 4c Siat4-C |
| Database Links | Reactome: R-HSA-1912420 Reactome: R-HSA-2022854 Reactome: R-HSA-4085001 Reactome: R-HSA-9037629 Reactome: R-HSA-9683673 Reactome: R-HSA-9694548 Reactome: R-HSA-9694719 Reactome: R-HSA-975577 Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi Apparatus Golgi Stack Membrane Single-Pass Type Ii Membrane Protein Secreted Membrane-Bound Form In Trans Cisternae Of Golgi Secreted Into The Body Fluid |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4 antibody Anti-Alpha 2 -3-St 4 antibody Anti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 4 antibody Anti-Alpha 2 -3-Sialyltransferase Iv antibody Anti-Gal-Nac6s antibody Anti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibody Anti-Gal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase antibody Anti-N-Acetyllactosaminide Alpha-2 -3-Sialyltransferase antibody Anti-Sat-3 antibody Anti-St-4 antibody Anti-St3gal Iv antibody Anti-St3galiv antibody Anti-St3gala.2 antibody Anti-Stz antibody Anti-Sialyltransferase 4c antibody Anti-Siat4-C antibody Anti-ST3GAL4 antibody Anti-CGS23 antibody Anti-NANTA3 antibody Anti-SIAT4C antibody Anti-STZ antibody |
Information sourced from Uniprot.org
