| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 1Alpha 2 -3-St 1Beta-Galactoside Alpha-2 -3-Sialyltransferase 1Gal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseMonosialoganglioside SialyltransferaseSiatflSt3gal ISt3galiSt3gala.1St3oSialyltransferase 4aSiat4-A |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinTrans-Golgi Network MembraneSecretedMembrane-Bound Form In Medial And Trans Cisternae Of GolgiSecreted Into The Body Fluid |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 1 antibodyAnti-Alpha 2 -3-St 1 antibodyAnti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 1 antibodyAnti-Gal-Nac6s antibodyAnti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibodyAnti-Monosialoganglioside Sialyltransferase antibodyAnti-Siatfl antibodyAnti-St3gal I antibodyAnti-St3gali antibodyAnti-St3gala.1 antibodyAnti-St3o antibodyAnti-Sialyltransferase 4a antibodyAnti-Siat4-A antibodyAnti-ST3GAL1 antibodyAnti-SIAT4 antibodyAnti-SIAT4A antibody |
Information sourced from Uniprot.org
