| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SS18L1 (90-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SS18L1 |
| Gene ID: |
26039 |
| Uniprot ID: |
CREST_HUMAN |
| Immunogen Region: |
90-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-270 of human SS18L1 (NP_945173.1). |
| Immunogen Sequence: |
LTQSGSSQGLHSQGSLSDAI STGLPPSSLLQGQIGNGPSH VSMQQTAPNTLPTTSMSISG PGYSHAGPASQGVPMQGQGT IGNYVSRTNINMQSNPVSMM QQQAATSHYSSAQGGSQHYQ GQSSIAMMGQGSQGSSMMGQ RPMAPYRPSQQGSSQQYLGQ EEYYGEQYSHSQGAAEPMGQ Q |
| Tissue Specificity | Ubiquitous.with lowest levels in spleen. |
| Function | Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. |
| Protein Name | Calcium-Responsive TransactivatorSs18-Like Protein 1Syt Homolog 1 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Nuclear BodiesColocalizes With Sgo1 At Kinetochore |
| Alternative Antibody Names | Anti-Calcium-Responsive Transactivator antibodyAnti-Ss18-Like Protein 1 antibodyAnti-Syt Homolog 1 antibodyAnti-SS18L1 antibodyAnti-CREST antibodyAnti-KIAA0693 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
