| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRF (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRF |
| Gene ID: |
6722 |
| Uniprot ID: |
SRF_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SRF (NP_003122.1). |
| Immunogen Sequence: |
MLPTQAGAAAALGRGSALGG SLNRTPTGRPGGGGGTRGAN GGRVPGNGAGLGPGRLEREA AAAAATTPAPTAGALYSGSE GDSESGEEEELGAERRGLKR SLSEMEIGMVVGGPEASAAA TGGYGPVSGAVSGAKPGKKT RGRVKIKMEFIDNKLRRYTT FSKRKTGIMKKAYELSTLTG TQVLLLVASETGHVYTFATR KLQPMITSETGKALIQTCLN SPDSPPRSDPTTDQRMSAT |
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. |
| Protein Name | Serum Response FactorSrf |
| Database Links | Reactome: R-HSA-5663220Reactome: R-HSA-9031628Reactome: R-HSA-9634638Reactome: R-HSA-9733709Reactome: R-HSA-9768777 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Serum Response Factor antibodyAnti-Srf antibodyAnti-SRF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
