| Post Translational Modifications | Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. |
| Function | Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. |
| Protein Name | Src Kinase Signaling Inhibitor 1Snap-25-Interacting ProteinSnipP130cas-Associated ProteinP140cap |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonDendritePresynapsePostsynapsePostsynaptic DensityLocalized To The Perinuclear RegionLamellopodiaCortical Actin And Actin Stress Fibers But Not To Focal AdhesionsStrongly Expressed In Axons And Dendrites Of The Ca1 And Ca3 Hippocampal Regions And Of The Dentate GyrusDetected In Both Presynapses And Postsynapses And Enriched In Postsynaptic Density Fractions |
| Alternative Antibody Names | Anti-Src Kinase Signaling Inhibitor 1 antibodyAnti-Snap-25-Interacting Protein antibodyAnti-Snip antibodyAnti-P130cas-Associated Protein antibodyAnti-P140cap antibodyAnti-SRCIN1 antibodyAnti-KIAA1684 antibodyAnti-P140 antibodyAnti-SNIP antibody |
Information sourced from Uniprot.org
