| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRC kinase signaling inhibitor 1 (811-860 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRCIN1 |
| Gene ID: |
80725 |
| Uniprot ID: |
SRCN1_HUMAN |
| Immunogen Region: |
811-860 aa |
| Specificity: |
p140Cap Polyclonal Antibody detects endogenous levels of p140Cap protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human SNIP at the amino acid range 811-860 |
| Post Translational Modifications | Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. |
| Function | Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. |
| Protein Name | Src Kinase Signaling Inhibitor 1Snap-25-Interacting ProteinSnipP130cas-Associated ProteinP140cap |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonDendritePresynapsePostsynapsePostsynaptic DensityLocalized To The Perinuclear RegionLamellopodiaCortical Actin And Actin Stress Fibers But Not To Focal AdhesionsStrongly Expressed In Axons And Dendrites Of The Ca1 And Ca3 Hippocampal Regions And Of The Dentate GyrusDetected In Both Presynapses And Postsynapses And Enriched In Postsynaptic Density Fractions |
| Alternative Antibody Names | Anti-Src Kinase Signaling Inhibitor 1 antibodyAnti-Snap-25-Interacting Protein antibodyAnti-Snip antibodyAnti-P130cas-Associated Protein antibodyAnti-P140cap antibodyAnti-SRCIN1 antibodyAnti-KIAA1684 antibodyAnti-P140 antibodyAnti-SNIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
