| Function | Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release. Spexin-1: Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity. |
| Protein Name | SpexinNpqNeuropeptide QSpexin Hormone Cleaved Into - Spexin-1 - Spexin-2Npq 53-70 |
| Database Links | |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmic VesicleSecretory VesicleSecreted Via The Classical Er/Golgi-Dependent Pathway Into The Extracellular Medium Largely As A Full-Length Protein Without The Signal PeptideAnd Not As A Hydrolyzed And Amidated PeptideLocalized Extracellularly Surrounding The Villous Trophoblastic CellsDetected In The Serum |
| Alternative Antibody Names | Anti-Spexin antibodyAnti-Npq antibodyAnti-Neuropeptide Q antibodyAnti-Spexin Hormone Cleaved Into - Spexin-1 - Spexin-2 antibodyAnti-Npq 53-70 antibodyAnti-SPX antibodyAnti-C12orf39 antibody |
Information sourced from Uniprot.org
