Anti-SPRY3 antibody (C-Term) (STJ116873)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SPRY3 (C-Term) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPRY3 |
| Gene ID | 10251 |
| Uniprot ID | SPY3_HUMAN |
| Immunogen Region | C-Term |
| Immunogen Sequence | TDDEDNCADEPCSCGPSSCF VRWAAMSLISLFLPCLCCYL PTRGCLHLCQQGYDSLRRPG CRCKRHTNTVCRKISSGSAP FPKAQEKSV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1). |
Additional Info
| Tissue Specificity | Widely expressed.particularly in the fetal tissues. Expressed in the brain with expression the highest in Purkinje cells in the cerebellum (at protein level). Expressed in the myocardium of the heart. |
| Function | Inhibits neurite branching, arbor length and neurite complexity. Inhibits EGF-mediated p42/44 ERK signaling. Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. |
| Protein Name | Protein Sprouty Homolog 3Spry-3Sprouty Rtk Signaling Antagonist 3Sprouty3 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Sprouty Homolog 3 antibodyAnti-Spry-3 antibodyAnti-Sprouty Rtk Signaling Antagonist 3 antibodyAnti-Sprouty3 antibodyAnti-SPRY3 antibody |
Information sourced from Uniprot.org