| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Sprouty-related, EVH1 domain-containing protein 3 (311-361 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPRED3 |
| Gene ID: | 399473 |
| Uniprot ID: | SPRE3_HUMAN |
| Immunogen Region: | 311-361 aa |
| Specificity: | This antibody detects endogenous levels of SPRE3 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human SPRE3 at the amino acid range 311-361 |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. |
| Protein Name | Sprouty-Related - Evh1 Domain-Containing Protein 3Spred-3 |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-6802953 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Sprouty-Related - Evh1 Domain-Containing Protein 3 antibodyAnti-Spred-3 antibodyAnti-SPRED3 antibodyAnti-EVE-3 antibody |
Information sourced from Uniprot.org