Anti-SPOP antibody (325-374) {FITC} (STJ506214)

SKU:
STJ506214-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SPOP (325-374) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 Mu g/Mu l
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SPOP
Gene ID: 8405
Uniprot ID: SPOP_HUMAN
Immunogen Region: 325-374
Immunogen: Synthetic peptide corresponding to amino acids within region 325-374 on human SPOP protein.
Function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1.this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability.
Protein Name Speckle-Type Poz Protein
Hib Homolog 1
Roadkill Homolog 1
Database Links Reactome: R-HSA-5632684
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Antibody Names Anti-Speckle-Type Poz Protein antibody
Anti-Hib Homolog 1 antibody
Anti-Roadkill Homolog 1 antibody
Anti-SPOP antibody

Information sourced from Uniprot.org

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