| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Meiotic recombination protein SPO11 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPO11 |
| Gene ID: |
23626 |
| Uniprot ID: |
SPO11_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SPO11 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human SPO11 |
| Function | Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. |
| Protein Name | Meiotic Recombination Protein Spo11Cancer/Testis Antigen 35Ct35 |
| Database Links | Reactome: R-HSA-912446 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Meiotic Recombination Protein Spo11 antibodyAnti-Cancer/Testis Antigen 35 antibodyAnti-Ct35 antibodyAnti-SPO11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
