| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SPO11 |
| Gene ID: |
23626 |
| Uniprot ID: |
SPO11_HUMAN |
| Immunogen Region: |
269-358 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 269-358 of human SPO11 (NP_937998.1). |
| Immunogen Sequence: |
AIRWLGLLPSDLKRLNVPKD SLIPLTKRDQMKLDSILRRP YVTCQPFWRKEMEIMADSKM KAEIQALTFLSSDYLSRVYL PNKLKFGGWI |
| Tissue Specificity | Highly expressed in testis. |
| Function | Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. |
| Protein Name | Meiotic Recombination Protein Spo11Cancer/Testis Antigen 35Ct35 |
| Database Links | Reactome: R-HSA-912446 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Meiotic Recombination Protein Spo11 antibodyAnti-Cancer/Testis Antigen 35 antibodyAnti-Ct35 antibodyAnti-SPO11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
