Anti-SPIRE1 antibody (STJA0004409)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human SPIRE1
General Information
| Short Description | Rabbit polyclonal anti-Protein Spire Homolog 1 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.14 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SPIRE1 |
| Gene ID | 56907 |
| Uniprot ID | SPIR1_HUMAN |
| Immunogen | Fusion protein of human SPIRE1 |
Additional Info
| Function | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1. |
| Protein Name | Protein Spire Homolog 1Spir-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic Vesicle MembraneDetected At The Cleavage Furrow During Asymmetric Oocyte Division And Polar Body ExtrusionPunctate Spots In Perinuclear Region And CytoplasmColocalized With Rab11 |
| Alternative Antibody Names | Anti-Protein Spire Homolog 1 antibodyAnti-Spir-1 antibodyAnti-SPIRE1 antibodyAnti-KIAA1135 antibodyAnti-SPIR1 antibody |
Information sourced from Uniprot.org